CBDA vs CBD Understanding the difference in under 30 seconds.

CBD vs CBDa

Short Answer: CBDA is the precursor compound to CBD.

Should should I take CBDa 

1. It is a phyto anti-inflammatory agent that closely resemble that of other common nonsteroidal ant-inflammatory drugs (NSAIDs).

2. More potent treatment for nausea and anxiety (cancer patients)

3. Anti-tumor properties (especially breast cancer cells)

Long Explanation

To understand CBD vs CBDa, I want to introduce a new term – CBGA. All the major cannabinoids present in the cannabis plant and hemp plant first develop as “mother of all cannabinoids”, cannabigerolic acid (CBGA). Depending on the cannabis strain and its unique plant enzymes, CBGA will be converted into varying combination of three major acidic cannabinoids precursor compounds: tetrahydrocannabinolic acid (THCa), cannabichromenic acid (CBCa), cannabidiolic acid (CBDa). From there these acidic precursors will convert to their non-acidic form during chemical reaction called thermal decarboxylation. THCa becomes THC, CBDa converts to CBD.

Like CBD, CBDa interacts with the body’s endocannabinoid system as a phytocannabinoid and may provide a range of health benefits. Early studies have shown that CBDa is a more potent treatment for nausea and anxiety. A 2013 study from scientists in Guelph, Canada, found that CBDa was a thousand times more powerful than CBD in binding to serotonin receptors linked to anti-nausea and anti-anxiety effects when administered alongside low doses of the traditional anti-nausea drug for chemotherapy patients, ondansetron (OND). With the greater potency, an isolated form of CBDa can be used in different ways to bring relief to patients undergoing cancer treatment.

Although all cannabis and hemp plants contain CBDa, most of it will be converted to CBD during the decarboxylation process either through high temperatures such as smoking or during the extraction process. So how can you get a health dose of CBDa?

There are several ways –

  1. raw cannabis and hemp plant materials contain CBDa as a natural cannabinoid. You can eat or juice raw cannabis as a way to get more CBDa
  2. Raw unfiltered hemp oil products contains CBDa. All of our CBD oil contain organic hemp seed oil. This is a great way to get the benefits of the entourage effect
  3. Comb through the lab report to see if the particular CBD oil contain any CBDa. Since we use a proprietary method of extraction, our Broad Spectrum CBD oil do contain a small amount of CBDa

Potential benefits of CBDa

Though the majority of cannabinoids bind with either CB1 or CB2 receptors directly, CBDa doesn’t function the same way. Rather, it corresponds with the endocannabinoid system by impeding the cyclooxygenase-2 (COx-2) enzyme. COx-2 enzyme is affiliated with inflammation after an infection or injury, so by inhibiting COX-2 enzymes, CBDa may have the potential benefits of alleviate inflammation and pain relief.

The acidic form of cannabinoids are thought to not have any potent effects on human health. This is because they affect the body’s cannabinoid receptors in different ways. As a result, most research has focused primarily on CBD and THC.

But new research is is challenging this idea.

In 2008, researchers noticed that the molecular structure of CBDa is very similar to other non-steroidal anti-inflammatory drugs. The research team then investigated and concluded that CBDa products demonstrated the same potential to tackle inflammation as NSAIDs.

Studies have shown it to be a thousand times more powerful than CBD in binding to a specific serotonin receptor linked to anti-nausea and anti-anxiety effects when administered alongside low-doses of traditional anti-nausea drug for chemotherapy patients.

Further research is needed because despite it demonstrating therapeutic potential, CBDa is quite unstable, as seen by its gradual decarboxylation at room temperature.

Research

Cannabinoid Profiling of Hemp Seed oil by Liquid Chromatography Coupled to High-Resolution Mass Spectrometry

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381057/

Cannabidiolic Acid as a Selective Cyclooxygenase-2 Inhibitory Component in Cannabis

https://dmd.aspetjournals.org/content/36/9/1917.long

Effect of low doses of cannabidiolic acid and ondansetron on Li-Cl-induced conditioned gaping (a model of nausea-induced behavior) in rats

https://pubmed.ncbi.nlm.nih.gov/23488964/

Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT receptors activation

https://pubmed.ncbi.nlm.nih.gov/23121618/

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